1103: Astrocyte polarization in perinatal white matter injury and its contribution to disease outcomes
نویسندگان
چکیده
منابع مشابه
Hemodynamic and Metabolic Correlates of Perinatal White Matter Injury Severity
BACKGROUND AND PURPOSE Although the spectrum of perinatal white matter injury (WMI) in preterm infants is shifting from cystic encephalomalacia to milder forms of WMI, the factors that contribute to this changing spectrum are unclear. We hypothesized that the variability in WMI quantified by immunohistochemical markers of inflammation could be correlated with the severity of impaired blood oxyg...
متن کاملBasic Sciences Differential Susceptibility to Axonopathy in Necrotic and Non-Necrotic Perinatal White Matter Injury
Background and Purpose—White matter injury (WMI) is the leading cause of brain injury in preterm survivors and results in myelination failure. Although axonal degeneration occurs in necrotic lesions, the role of axonopathy in myelination failure remains controversial for diffuse non-necrotic WMI, which is currently the major form of WMI. We determined the burden of axonopathy in diffuse lesions...
متن کاملDifferential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury.
BACKGROUND AND PURPOSE White matter injury (WMI) is the leading cause of brain injury in preterm survivors and results in myelination failure. Although axonal degeneration occurs in necrotic lesions, the role of axonopathy in myelination failure remains controversial for diffuse non-necrotic WMI, which is currently the major form of WMI. We determined the burden of axonopathy in diffuse lesions...
متن کاملAssessment the Contributing Factors to Head Injury and its Health Outcomes in Baghdad Teaching Hospital
Background: Every year, approximately 1.25 million people are killed as a result of traffic accidents. Between 20 million and 50 million other people are exposed to non-fatal injuries and many become disabled. The study aims to assess the contributing factors of traumatic head injuries and its health outcomes in Baghdad city. Methodology: It was conducted descriptive study to determine the con...
متن کاملWhite Matter Injury of Prematurity: Its Mechanisms and Clinical Features
A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and fu...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2020
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2019.11.1115